If doing so, you’ll notice that the mouse works also when your keyboard is not connected to your computer, then check the keyboard for faulty keys and replace it (if required) to fix ‘Mouse moves but won’t click on Windows 10’ issue. Thus, you need to ensure that your keyboard keys are in perfect condition for working properly.
Thus, first and foremost, to troubleshoot the given ‘Windows 10 not responding to mouse clicks’ issue, make sure to try some basic troubleshooting steps such as.
As faulty keyboard keys itself can prevent the mouse from performing the required ‘Right or Left’ click actions.